Wednesday’s draw got here after Forest got here by way of a dramatic 4-3 penalty shootout win over Wolves, Joe Hodge seeing the decisive spot-kick saved by Dean Henderson after a 1-1 attract 90 minutes.
The primary leg is scheduled to happen on the Metropolis Floor on the week of January 23 earlier than the Previous Trafford return every week later.
United got here by way of a difficult encounter with Charlton on Tuesday, Marcus Rashford scoring a late brace off the bench.
Southampton booked a tie with Nottingham Forest after stunning Manchester Metropolis 2-0 at St Mary’s.
First-half targets from Sekou Mara and Moussa Djenepo secured an enormous increase for Nathan Jones amid Saints’ relegation battle, ending Pep Guardiola’s excellent document of 15-straight wins in home cup quarter-finals.
Newcastle, who beat Leicester 2-0 on Tuesday, will host the return leg at St James’ Park.
